CD80 Antibody [1G10] (Biotin)
Product Specifications
Background
CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is upregulated after activation by various means including stimulation by LPS, IL-4, and surface Ig receptor crosslinking with peak expression occurring between 48 and 72 hours post-activation. The interaction of CD80 with its ligands, CD28 and CD152 (CTLA-4), provides a potent costimulatory signal for T cells activated through the CD3/T cell receptor complex. The monoclonal antibody 1G10 blocks binding of CTLA-4 to CD80 but it does not block stimulation of T cells by natural antigen-presenting cells.
NCBI Gene ID
12519
Swiss Prot
Q00609
Accession Number
Q00609
Host
Rat
Reactivity
Mouse
Immunogen
Activated 5C2 cells
Clonality
Monoclonal
Clone
[1G10]
Conjugation
Biotin
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Concentration
0.5 mg/mL
Buffer
Supplied in PBS/NaN3
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG2a
Specificity
CD80
Applications Notes
CD80 Antibody [1G10] for use in flow cytometry and immunoprecipitation assays.
Symbol
Cd80
NCBI Official Name
CD80 antigen
NCBI Organism
Mus musculus
Other Product Names
B7-1, Ly-53
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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