CD154 Antibody [MR1]
Product Specifications
Background
CD154, formerly known as CD40 ligand and gp39, is a type II integral membrane protein and a member of the tumor necrosis factor (TNF) family of ligands. It is an important accessory molecule in T cell-B cell costimulatory interactions and is expressed predominantly on activated CD4+ T lymphocytes. It is also present on the surface of activated Th0, Th1, and Th2 T cell clones. Its expression is transient and cyclosporin-sensitive. The MR1 monoclonal antibody binds to murine CD154 with high affinity, blocks binding to CD40, and blocks CD154 function. Administration of this antibody to mice blocks the ability to mount primary and secondary immune responses to TD antigens yet does not alter the immune response to TI antigens.
NCBI Gene ID
21947
Swiss Prot
P27548
Accession Number
P27548
Host
Hamster
Reactivity
Mouse
Immunogen
Activated mouse Th1 clone D1.6
Clonality
Monoclonal
Clone
[MR1]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Concentration
0.5 mg/mL
Buffer
Supplied in PBS
Modification
None
Shipping Conditions
Dry Ice
Storage Conditions
Store vial at -20˚ C
Fragment
IgG
Specificity
CD154
Applications Notes
CD154 Antibody [MR1] for use in flow cytometry, immunohistochemistry, immunoprecipitation, ELISA, and blocking assays.
Symbol
Cd40lg
NCBI Official Name
CD40 ligand
NCBI Organism
Mus musculus
Other Product Names
CD40L, CD40 ligand, gp39
Tested Applications
WB, IHC-P, IHC-Fr, ICC, Flow, IP, Adhesion
Physical Properties
Liquid
Frequently Asked Questions
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