CD22 Antibody [2D6]
Product Specifications
Background
CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation.
NCBI Gene ID
12483
Swiss Prot
P35329
Accession Number
P35329
Host
Rat
Reactivity
Mouse
Immunogen
Splenic lymphocyte plasma membranes from CBA x C57 F1 mice
Clonality
Monoclonal
Clone
[2D6]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Stem Cell, Immunology
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG1
Specificity
CD22
Applications Notes
CD22 Antibody [2D6] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and activation assays.
Symbol
Cd22
NCBI Official Name
CD22 antigen
NCBI Organism
Mus musculus
Other Product Names
Lyb-8, Leu-14, BL-CAM
Tested Applications
ELISA, WB, IHC-P, Flow, IP
Physical Properties
Liquid
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