CD19 Antibody [6D5] (Biotin)
Product Specifications
Background
CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e. B220+/CD43+/HSA+) through fully differentiated B cell stages. Terminally differentiated plasma cells do not express CD19. In humans, the CD19 molecule on the surface of mature B cells associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to provide signal transduction and promote cellular activation. All splenic and peritoneal IgM+ cells of both B-1 and B-2 lineages are CD19+, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites. Studies with CD19-deficient mice have suggested that this molecule may not be required for normal generation and maturation of B cells in the bone marrow. The monoclonal antibody 6D5 recognizes the same epitope as the published clone, 1D3.
NCBI Gene ID
12478
Swiss Prot
P25918
Accession Number
P25918
Host
Rat
Reactivity
Mouse
Immunogen
Mouse CD19-expressing K562 human erythroleukemia cells
Clonality
Monoclonal
Clone
[6D5]
Conjugation
Biotin
Type
Primary Antibodies
Field of Research
Immunology
Concentration
0.5 mg/mL
Buffer
Supplied in PBS/NaN3
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=98-659
Fragment
IgG2a
Specificity
CD19
Applications Notes
CD19 Antibody [6D5] for use in flow cytometry, immunohistochemistry, immunoprecipitation, and separation assays.
Symbol
Cd19
NCBI Official Name
CD19 antigen
NCBI Organism
Mus musculus
Other Product Names
B4, Leu-12
Tested Applications
ELISA, WB, IHC-P, IHC-Fr, IP, Multiplex
Physical Properties
Liquid
Curated Selection
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