CD11b Antibody [M1/70] (FITC)
Product Specifications
Background
CD11b, the integrin alphaM subunit, combines with CD18, the integrin beta2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils. Cross-reaction of M1/70 to human CD11b has been observed on monocytes, polymorphonuclear leukocytes, and NK cells.
NCBI Gene ID
16409
Swiss Prot
P05555
Accession Number
P05555
Host
Rat
Reactivity
Mouse, Human, Rhesus Monkey, Baboon, Rabbit
Immunogen
C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes
Clonality
Monoclonal
Clone
[M1/70]
Conjugation
FITC
Type
Primary Antibodies
Field of Research
Immunology, Neuroscience, Signal Transduction
Concentration
0.5 mg/mL
Buffer
Supplied in PBS/NaN3
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=98-643
Fragment
IgG2b
Specificity
CD11b
Applications Notes
CD11b Antibody [M1/70] for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.
Symbol
Itgam
NCBI Official Name
Integrin alpha M
NCBI Organism
Mus musculus
Other Product Names
Integrin alphaM, Mac-1alpha, Mac-1, Mo1, CR3, C3biR
Tested Applications
ELISA, Flow
Physical Properties
Liquid
Curated Selection
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