CD11b Antibody [3A33]
Product Specifications
Background
CD11b (integrin alphaM subunit) combines with CD18 (integrin beta2 subunit) to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1 (CD54) . Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils.
NCBI Gene ID
16409
Swiss Prot
P05555
Accession Number
P05555
Host
Rat
Reactivity
Mouse
Immunogen
Peritoneal macrophages from B6D2 hybrid mice
Clonality
Monoclonal
Clone
[3A33]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Neuroscience, Signal Transduction
Concentration
0.5 mg/mL
Buffer
Supplied in PBS
Modification
None
Shipping Conditions
Dry Ice
Storage Conditions
Store vial at -20˚ C
Fragment
IgG2a
Specificity
CD11b
Applications Notes
CD11b Antibody [3A33] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and blocking assays.
Symbol
Itgam
NCBI Official Name
Integrin alpha M
NCBI Organism
Mus musculus
Other Product Names
Integrin alphaM, Mac-1alpha, Mac-1, Mo1, CR3, C3biR
Tested Applications
ELISA, Flow, IP, Neutralization Assay, Multiplex
Physical Properties
Liquid
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