CD5 Antibody [B19.1]
Product Specifications
Background
CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B-cell antigen CD72. The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells. Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors.
NCBI Gene ID
12507
Swiss Prot
P13379
Accession Number
P13379
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
[B19.1]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Signal Transduction
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=98-596
Fragment
IgG2a
Specificity
CD5
Applications Notes
CD5 Antibody [B19.1] for use in flow cytometry, western blotting, and immunoprecipitation assays.
Symbol
Cd5
NCBI Official Name
CD5 antigen
NCBI Organism
Mus musculus
Other Product Names
Lyt-1, Ly-1, Lymphocyte antigen 1, Ly-12, Ly-A, T1, Tp67
Tested Applications
ELISA, WB, IHC-P, IHC-Fr, Flow
Physical Properties
Liquid
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
