CD4 Antibody [GK1.5]
Product Specifications
Background
CD4 is a type I transmembrane glycoprotein expressed on most thymocytes and the helper/inducer subpopulation of mature T lymphocytes of all mouse strains tested. CD4 has also been detected at low density on pluripotent hematopoietic stem cells, bone marrow myeloid precursors, and intrathymic lymphoid precursors. The CD4 antigen functions as a co-receptor, interacting with class II major histocompatability complex (MHC) molecules in the recognition of foreign antigens by T cells. In vivo and in vitro treatment with the GK1.5 monoclonal antibody effectively depletes CD4+ cells. GK1.5 also blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.
NCBI Gene ID
12504
Swiss Prot
P06332
Accession Number
P06332
Host
Rat
Reactivity
Mouse
Immunogen
Mouse CTL clone V4
Clonality
Monoclonal
Clone
[GK1.5]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=98-583
Fragment
IgG2b
Specificity
CD4
Applications Notes
CD4 Antibody [GK1.5] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, depletion, separation, and blocking assays.
Symbol
Cd4
NCBI Official Name
CD4 antigen
NCBI Organism
Mus musculus
Other Product Names
L3T4, Ly-4
Tested Applications
WB, ICC
Physical Properties
Liquid
Curated Selection
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