Cyclin D1 (phospho Ser90) Antibody
Product Specifications
Background
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
NCBI Gene ID
595
Swiss Prot
P24385
Accession Number
NP_444284.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Cyclin D1 (phospho Ser90) antibody was raised against a peptide sequence around phosphorylation site of serine 90 (F-L-S (p) -L-E) derived from Human Cyclin D1 .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
31 kDa
Fragment
IgG
Specificity
The antibody detects endogenous level of Cyclin D1 only when phosphorylated at serine 90.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
CCND1
NCBI Official Name
Cyclin D1
NCBI Organism
Homo sapiens
Background Reference 01
Sewing A, Müller R (1994) Oncogene 9, 2733-6
Other Product Names
BCL1, CCND1, CYL-1, PRAD1, PRAD1 oncogene
Tested Applications
WB
Protein ID
116152
Physical Properties
Liquid
Curated Selection
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NBP2-89871AF647 0.1 mL
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