HDAC6 (phospho Ser22) Antibody
Product Specifications
Background
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
NCBI Gene ID
10013
Swiss Prot
Q9UBN7
Accession Number
NP_006035.2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
HDAC6 (phospho Ser22) antibody was raised against a peptide sequence around phosphorylation site of serine 22 (P-Q-S (p) -P-P) derived from Human HDAC6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
131 kDa
Fragment
IgG
Specificity
The antibody detects endogenous level of HDAC6 only when phosphorylated at serine 22.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
HDAC6
NCBI Official Name
Histone deacetylase 6
NCBI Organism
Homo sapiens
Background Reference 01
Chen S, Owens GC, Makarenkova H, Edelman DB (2010) PLoS One 5, e10848.
Other Product Names
HD6, HDA6, Histone deacetylase 6, JM21
Tested Applications
WB
Protein ID
13128864
Physical Properties
Liquid
Curated Selection
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