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Adrenergic Receptor beta2 (phospho Ser346) Antibody

Product Specifications

Background

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

NCBI Gene ID

154

Swiss Prot

P07550

Accession Number

NP_000015.1

Host

Rabbit

Reactivity

Human

Immunogen

Adrenergic Receptor beta2 (phospho Ser346) antibody was raised against a peptide sequence around phosphorylation site of serine 346 (R-S-S (p) -L-K) derived from Human Adrenergic Receptor beta2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

40 kDa

Fragment

IgG

Specificity

The antibody detects endogenous level of Adrenergic Receptor beta2 only when phosphorylated at serine 346.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

ADRB2

NCBI Official Name

Adrenoceptor beta 2, surface

NCBI Organism

Homo sapiens

Background Reference 01

Gao S, Malbon C, Wang HY (2014) J Mol Signal 9, 3

Background Reference 02

24690384 Curated Info

Background Reference 03

Vistein R, Puthenveedu MA (2013) Proc Natl Acad Sci U S A 110, 15289-94

Background Reference 04

Gimenez LE, et al. (2012) J Biol Chem 287, 9028-40

Other Product Names

ADRB2R, B2AR, adrenergic receptor, beta-2

Tested Applications

WB

Protein ID

4501969

Physical Properties

Liquid

Frequently Asked Questions

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