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YAP (phospho Ser127) Antibody

Product Specifications

Background

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact.

NCBI Gene ID

10413

Swiss Prot

P46937

Accession Number

NP_001123617.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

YAP (phospho Ser127) antibody was raised against a peptide sequence around phosphorylation site of serine127 (A-H-S (p) -S-P) derived from Human YAP .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=80-002

Calculated Molecular Weight

65 kDa

Fragment

IgG

Specificity

The antibody detects endogenous level of YAP only when phosphorylated at serine 127.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

YAP1

NCBI Official Name

Yes-associated protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Sorrentino G, et al. (2014) Nat Cell Biol 16, 357-66

Background Reference 02

Yang S, et al. (2014) Cell Signal 26, 343-51

Background Reference 03

Sun W, et al. (2014) Mol Biol Rep 41, 947-56

Other Product Names

YAP65, YAP1

Tested Applications

WB

Protein ID

194306653

Physical Properties

Liquid

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