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SREBP-1 (phospho Ser439) Antibody

Product Specifications

Background

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway By similarity. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') . Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') .

NCBI Gene ID

6720

Swiss Prot

P36956

Accession Number

NP_001005291.1

Host

Rabbit

Reactivity

Human, Rat

Immunogen

SREBP-1 (phospho Ser439) antibody was raised against a peptide sequence around phosphorylation site of serine439 (Q-S-S (p) -P-L) derived from Human SREBP-1 .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

122 kDa

Fragment

IgG

Specificity

The antibody detects endogenous level of SREBP-1 only when phosphorylated at serine 439.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

SREBF1

NCBI Official Name

Sterol regulatory element binding transcription factor 1

NCBI Organism

Homo sapiens

Background Reference 01

Bengoechea-Alonso MT, Ericsson J (2006) Cell Cycle 5, 1708-18

Other Product Names

SRBP1, SREBF1, SREBP1, sterol regulatory element-binding protein 1

Tested Applications

WB

Protein ID

52630419

Physical Properties

Liquid

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