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VE-Cadherin (phospho Tyr731) Antibody

Product Specifications

Background

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen.

NCBI Gene ID

1003

Swiss Prot

P33151

Accession Number

NP_001786.2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

VE-Cadherin (phospho Tyr731) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine731 (H-I-Y (p) -G-Y) derived from Human VE-Cadherin.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=80-000

Calculated Molecular Weight

130 kDa

Fragment

IgG

Specificity

The antibody detects endogenous level of VE-Cadherin only when phosphorylated at tyrosine 731.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

CDH5

NCBI Official Name

Cadherin 5, type 2 (vascular endothelium)

NCBI Organism

Homo sapiens

Background Reference 01

Wessel F, et al. (2014) Nat Immunol 15, 223-30

Background Reference 02

Sawada J, et al. (2012) Cancer Cell 22, 235-49

Background Reference 03

Turowski P, et al. (2008) J Cell Sci 121, 29-37

Other Product Names

Vascular endothelial cadherin, VE-cadherin, 7B4 antigen, CDH5, CD144 antigen

Tested Applications

WB

Protein ID

166362713

Physical Properties

Liquid

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