Smad2 (phospho Ser250) Antibody
Product Specifications
Background
Transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase. SMAD2 is a receptor-regulated SMAD (R-SMAD) . May act as a tumor suppressor in colorectal carcinoma.
NCBI Gene ID
4087
Swiss Prot
Q15796
Accession Number
NP_001003652.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Smad2 (phospho Ser250) antibody was raised against a peptide sequence around phosphorylation site of serine250 (E-L-S (p) -P-T) derived from Human Smad2 .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
65 kDa
Fragment
IgG
Specificity
The antibody detects endogenous level of Smad2 only when phosphorylated at serine 250.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
SMAD2
NCBI Official Name
SMAD family member 2
NCBI Organism
Homo sapiens
Background Reference 01
Fransvea E, Mazzocca A, Antonaci S, Giannelli G (2009) Hepatology 49, 839-50 . Funaba M, Zimmerman CM, Mathews LS (2002) J Biol Chem 277, 41361-8. Kretzschmar M, Doody J, Timokhina I, Massagué J (1999) Genes Dev 13, 804-16 .
Other Product Names
JV18-1, MADH2, Mad-related protein 2, Mothers against DPP homolog 2
Tested Applications
WB
Protein ID
51173730
Physical Properties
Liquid
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