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HER2 (phospho Tyr1112) Antibody

Product Specifications

Background

Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.

NCBI Gene ID

2064

Swiss Prot

P04626

Accession Number

NP_001005862.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

HER2 (phospho Tyr1112) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1112 (Q-R-Y (p) -S-E) derived from Human HER2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

150 kDa

Fragment

IgG

Specificity

The antibody detects endogenous level of HER2 only when phosphorylated at tyrosine 1112.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

ERBB2

NCBI Official Name

V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

NCBI Organism

Homo sapiens

Background Reference 01

Chuang TD, et al. (2010) J Biol Chem 285, 23598-606

Background Reference 02

Bhuvaneswari R, Gan YY, Soo KC, Olivo M (2009) Mol Cancer 8, 94

Background Reference 03

Thelemann A, et al. (2005) Mol Cell Proteomics 4, 356-76

Other Product Names

C-erbB-2, NGL, NEU proto-oncogene, MLN 19

Tested Applications

WB

Protein ID

54792098

Physical Properties

Liquid

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