DRP1 (phospho Ser637) Antibody

Product Specifications

Background

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation.

NCBI Gene ID

10059

Swiss Prot

O00429

Accession Number

NP_036192.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

DRP1 (phospho Ser637) antibody was raised against a peptide sequence around phosphorylation site of Serine 637 (K-L-S (p) -A-R) derived from Human DRP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

82 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of DRP1 only when phosphorylated at serine 637.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

DNM1L

NCBI Official Name

Dynamin 1-like

NCBI Organism

Homo sapiens

Background Reference 01

Shin H.-W., J. Biochem. 122:525-530 (1997) .

Background Reference 02

Hong Y.-R., Biochem. Biophys. Res. Commun. 249:697-703 (1998) .

Background Reference 03

Imoto M., J. Cell Sci. 111:1341-1349 (1998) .

Other Product Names

DLP1, DNM1L, DRP1, DVLP, Dymple

Tested Applications

Protein ID

171460914

Physical Properties

Liquid

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