MuSK (phospho Tyr755) Antibody

Product Specifications

Background

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane.

NCBI Gene ID

4593

Swiss Prot

O15146

Accession Number

NP_005583.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

MuSK (phospho Tyr755) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 755 (A-D-Y (p) -Y-K) derived from Human MuSK .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

97 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of MuSK only when phosphorylated at tyrosine 755.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

MUSK

NCBI Official Name

Muscle, skeletal, receptor tyrosine kinase

NCBI Organism

Homo sapiens

Background Reference 01

Valenzuela D.M., Neuron 15:573-584 (1995) .

Background Reference 02

Humphray S.J., Nature 429:369-374 (2004) .

Background Reference 03

Bergamin E., Mol. Cell 39:100-109 (2010) .

Other Product Names

MUSK, Muscle, skeletal

Tested Applications

Protein ID

5031927

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

48439031 100 µg

TRNAV20 Protein Lysate (Human) with C-Ha Tag

Ask

View Details

MBS734749-01 48 Well

Goat Soluble interleukin-1 receptor I ELISA Kit

Ask

View Details

MBS734749-02 96 Well

Goat Soluble interleukin-1 receptor I ELISA Kit

Ask

View Details

MBS734749-03 5x 96 Well

Goat Soluble interleukin-1 receptor I ELISA Kit

Ask

View Details

MBS734749-04 10x 96 Well

Goat Soluble interleukin-1 receptor I ELISA Kit

Ask

View Details

EA101770 1x 48 Well (Pre-Coated)

Rat IFN gamma ELISA Kit, 1 x 48-well (pre-coated)

Ask

View Details