CSFR (phospho Tyr708) Antibody

Product Specifications

Background

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development.

NCBI Gene ID

1436

Swiss Prot

P07333

Accession Number

NP_001275634.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

CSFR (phospho Tyr708) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 708 (K-K-Y (p) -V-R) derived from Human CSFR .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

200 kDa

Fragment

IgG

Specificity

The Antibody detects endogenous levels of CSF1R only when phosphorylated at tyrosine 708.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

CSF1R

NCBI Official Name

Colony stimulating factor 1 receptor

NCBI Organism

Homo sapiens

Background Reference 01

Hampe A., Oncogene Res. 4:9-17 (1989) .

Background Reference 02

Andre C., Genomics 39:216-226 (1997) .

Other Product Names

C-FMS, CD115, CSF1R, FIM2, FMS

Tested Applications

Protein ID

27262659

Physical Properties

Liquid

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