TPH2 (phospho Ser19) Antibody

Product Specifications

Background

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

NCBI Gene ID

121278

Swiss Prot

Q8IWU9

Accession Number

NP_775489.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

TPH2 (phospho Ser19) antibody was raised against a peptide sequence around phosphorylation site of Serine 19 (G-F-S (p) -L-D) derived from Human TPH2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

56 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of TPH2 only when phosphorylated at serine 19.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

TPH2

NCBI Official Name

Tryptophan hydroxylase 2

NCBI Organism

Homo sapiens

Background Reference 01

Walther D.J., Science 299:76-76 (2003) .

Background Reference 02

Scherer S.E., Nature 440:346-351 (2006) .

Other Product Names

ADHD7, NTPH, TPH2

Tested Applications

Protein ID

31795563

Physical Properties

Liquid

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