SYK (phospho Tyr352) Antibody

Product Specifications

Background

Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion

NCBI Gene ID

6850

Swiss Prot

P43405

Accession Number

NP_001167638.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

SYK (phospho Tyr352) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 352 (S-P-Y (p) -A-D) derived from Human SYK.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

72 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of SYK only when phosphorylated at tyrosine 352.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

SYK

NCBI Official Name

Spleen tyrosine kinase

NCBI Organism

Homo sapiens

Background Reference 01

Yagi S., Biochem. Biophys. Res. Commun. 200:28-34 (1994) .

Background Reference 02

Law C.-L., J. Biol. Chem. 269:12310-12319 (1994) .

Other Product Names

SYK, KSYK, FLJ25043, FLJ37489

Tested Applications

Protein ID

21361553

Physical Properties

Liquid

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