GRIN2B (phospho Ser1303) Antibody

Product Specifications

Background

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B) . The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.

NCBI Gene ID

2904

Swiss Prot

Q13224

Accession Number

NP_000825.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

GRIN2B (phospho Ser1303) antibody was raised against a peptide sequence around phosphorylation site of Serine 1303 (Q-H-S (p) -Y-D) derived from Human GRIN2B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

170 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of GRIN2B only when phosphorylated at serine 1303.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

GRIN2B

NCBI Official Name

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B

NCBI Organism

Homo sapiens

Background Reference 01

Adams S.L., Biochim. Biophys. Acta 1260:105-108 (1995) .

Background Reference 02

Hess S.D., J. Pharmacol. Exp. Ther. 278:808-816 (1996) .

Background Reference 03

Mandich P., Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.

Other Product Names

GRIN2B, NMDE2, NME2, NR2B, NR3

Tested Applications

Protein ID

4504127

Physical Properties

Liquid

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