TAL-1 (phospho Ser122) Antibody

Product Specifications

Background

TAL-1 is a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2.

NCBI Gene ID

6886

Swiss Prot

P17542

Accession Number

NP_001274276.1

Host

Rabbit

Reactivity

Human, Rat

Immunogen

TAL-1 (phospho Ser122) antibody was raised against a peptide sequence around phosphorylation site of Serine 122 (Q-L-S (p) -P-P) derived from Human TAL-1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

45 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of TAL-1 only when phosphorylated at serine 122.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

TAL1

NCBI Official Name

T-cell acute lymphocytic leukemia 1

NCBI Organism

Homo sapiens

Background Reference 01

Aplan P.D., Mol. Cell. Biol. 10:6426-6435 (1990) .

Background Reference 02

Gregory S.G., Nature 441:315-321 (2006) .

Background Reference 03

Chen Q., J. Exp. Med. 172:1403-1408 (1990) .

Other Product Names

SCL, TAL1, TCL5

Tested Applications

Protein ID

4507363

Physical Properties

Liquid

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