PAK5/6 (phospho Ser602/Ser560) Antibody

Product Specifications

Background

This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development.

NCBI Gene ID

57144;56924

Swiss Prot

Q9P286; Q9NQU5

Accession Number

NP_065074.1

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

PAK5/6 (phospho Ser602/Ser560) antibody was raised against a peptide sequence around phosphorylation site of Serine 602/560 (R-K-S (p) -L-V) derived from Human PAK5/6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

75 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of PAK5/6 only when phosphorylated at serine 602/560.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

PAK5, PAK6

NCBI Official Name

P21 protein (Cdc42/Rac) -activated kinase 5, p21 protein (Cdc42/Rac) -activated kinase 6

NCBI Organism

Homo sapiens

Background Reference 01

Yang F., J. Biol. Chem. 276:15345-15353 (2001) .

Background Reference 02

Wagner T., Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.

Background Reference 03

Sjoeblom T., Science 314:268-274 (2006) .

Other Product Names

PAK5, PAK 6, kinase PAK6

Tested Applications

Protein ID

24308191

Physical Properties

Liquid

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