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MDC1 (phospho Ser513) Antibody

Product Specifications

Background

The MDC1 protein contains a forkhead homology-associated (FHA) domain and 2 BRCA1 (MIM 113705) C-terminal motifs (BRCTs) and is required for the intra-S-phase DNA damage checkpoint.

NCBI Gene ID

9656

Swiss Prot

Q14676

Accession Number

NP_055456.2

Host

Rabbit

Reactivity

Human

Immunogen

MDC1 (phospho Ser513) antibody was raised against a peptide sequence around phosphorylation site of Serine 513 (E-R-S (p) -Q-A) derived from Human MDC1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

226 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of MDC1 only when phosphorylated at serine 513.

Symbol

MDC1

NCBI Official Name

Mediator of DNA-damage checkpoint 1

NCBI Organism

Homo sapiens

Background Reference 01

Nagase T., DNA Res. 3:17-24 (1996) .

Background Reference 02

Shiina T., Genetics 173:1555-1570 (2006) .

Background Reference 03

Mungall A.J., Nature 425:805-811 (2003) .

Other Product Names

IER3, NFBD1, KIAA0170, DKFZp781A0122

Tested Applications

IHC

Protein ID

132626688

Physical Properties

Liquid

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