MAPKAPK2 (phospho Ser272) Antibody

Product Specifications

Background

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.

NCBI Gene ID

9261

Swiss Prot

P49137

Accession Number

NP_116584.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

MAPKAPK2 (phospho Ser272) antibody was raised against a peptide sequence around phosphorylation site of Serine 272 (A-I-S (p) -P-G) derived from Human MAPKAPK2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

45 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of MAPKAPK2 only when phosphorylated at serine 272.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

MAPKAPK2

NCBI Official Name

Mitogen-activated protein kinase-activated protein kinase 2

NCBI Organism

Homo sapiens

Background Reference 01

Zu Y.-L., Biochem. Biophys. Res. Commun. 200-1118-1124 (1994) .

Background Reference 02

The MGC Project Team; Genome Res. 14:2121-2127 (2004) .

Background Reference 03

Stokoe D., Biochem. J. 296:843-849 (1993) .

Other Product Names

MAPK2; , MAPKAPK2, RPS6KC1

Tested Applications

WB, IHC

Protein ID

32481209

Physical Properties

Liquid

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