Girdin (phospho Ser1417) Antibody

Product Specifications

Background

Girdin IS a ubiquitously expressed actin binding protein that plays an important role in the formation of stress fibers and lamellipodia. Subsequent to phosphorylation by Akt, Girdin accumulates at the leading edge of migrating cells and appears to be crucial for the integrity of the actin cytoskeleton and for cell migration.

NCBI Gene ID

55704

Swiss Prot

Q3V6T2

Accession Number

NP_060554.3

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Girdin (phospho Ser1417) antibody was raised against a peptide sequence around phosphorylation site of Serine 417 (L-E-M (p) -A-Q) derived from Human Girdin .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

216 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of Girdin only when phosphorylated at serine 1417.

Symbol

CCDC88A

NCBI Official Name

Coiled-coil domain containing 88A

NCBI Organism

Homo sapiens

Background Reference 01

Enomoto A., Dev. Cell 9:389-402 (2005) .

Background Reference 02

Simpson F., Traffic 6:442-458 (2005) .

Background Reference 03

Hillier L.W., Nature 434:724-731 (2005) .

Other Product Names

APE, GIV, GRDN, HkRP1, KIAA1212

Tested Applications

IHC

Protein ID

50897852

Physical Properties

Liquid

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