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EPS15 (phospho Tyr849) Antibody

Product Specifications

Background

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

NCBI Gene ID

2060

Swiss Prot

P42566

Accession Number

NP_001972.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

EPS15 (phospho Tyr849) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 849 (S-A-Y (p) -P-S) derived from Human Ephrin EPS15.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=79-910

Calculated Molecular Weight

100 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of EPS15 only when phosphorylated at tyrosine 849.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

EPS15

NCBI Official Name

Epidermal growth factor receptor pathway substrate 15

NCBI Organism

Homo sapiens

Background Reference 01

Wong W.T., Oncogene 9:1591-1597 (1994) .

Background Reference 02

Bernard O.A., Oncogene 9:1039-1045 (1994) .

Other Product Names

AF1P, MLLT5, EPS15, Protein Eps15

Tested Applications

WB

Protein ID

229577185

Physical Properties

Liquid

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