EPB41 (phospho Tyr660/418) Antibody

Product Specifications

Background

Elliptocytosis is a hematologic disorder characterized by elliptically shaped erythrocytes and a variable degree of hemolytic anemia. Inherited as an autosomal dominant, elliptocytosis results from mutation in any one of several genes encoding proteins of the red cell membrane skeleton. The form discussed here is the one found in the 1950s to be linked to Rh blood group and more recently shown to be caused by a defect in protein 4.1. 'Rh-unlinked' forms of elliptocytosis are caused by mutation in the alpha-spectrin gene, the beta-spectrin gene, or the band 3 gene.

NCBI Gene ID

2035

Swiss Prot

P11171

Accession Number

NP_001159477.1

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

EPB41 (phospho Tyr660/418) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 660/418 (N-I-Y (p) -I-R) derived from Human EPB41.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

60 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of EPB41 only when phosphorylated at tyrosine 660/418.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

EPB41

NCBI Official Name

Erythrocyte membrane protein band 4.1

NCBI Organism

Homo sapiens

Background Reference 01

Conboy J.G., Proc. Natl. Acad. Sci. U.S.A. 83:9512-9516 (1986) .

Background Reference 02

Tang T.K., Adv. Exp. Med. Biol. 241:81-95 (1988) .

Background Reference 03

Tang T.K., Proc. Natl. Acad. Sci. U.S.A. 85:3713-3717 (1988) .

Other Product Names

E41P, EPB4.1, band 4.1, P4.1

Tested Applications

Protein ID

260436831

Physical Properties

Liquid

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