Cyclin C (phospho Ser275) Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

892

Swiss Prot

P24863

Accession Number

NP_005181.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Cyclin C (phospho Ser275) antibody was raised against a peptide sequence around phosphorylation site of Serine 275 (N-G-S (p) -A-N) derived from Human Cyclin C.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

37 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of Cyclin C only when phosphorylated at serine 275.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

CCNC

NCBI Official Name

Cyclin C

NCBI Organism

Homo sapiens

Background Reference 01

Lew D.J., Cell 66:1197-1206 (1991) .

Background Reference 02

Li H., Genomics 32:253-259 (1996) .

Background Reference 03

Mungall A.J., Nature 425:805-811 (2003) .

Other Product Names

CG1C, cyclin C, SRB11

Tested Applications

WB, IHC

Protein ID

61676093

Physical Properties

Liquid

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