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CtBP1 (phospho Ser422) Antibody

Product Specifications

Background

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.

NCBI Gene ID

1487

Swiss Prot

Q13363

Accession Number

NP_001319.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

CtBP1 (phospho Ser422) antibody was raised against a peptide sequence around phosphorylation site of Serine 422 (A-P-S (p) -P-G) derived from Human CtBP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

48 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of CtBP1 only when phosphorylated at serine 422.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

CTBP1

NCBI Official Name

C-terminal binding protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Schaeper U., Proc. Natl. Acad. Sci. U.S.A. 92:10467-10471 (1995) .

Background Reference 02

Sewalt R.G.A.B., Mol. Cell. Biol. 19:777-787 (1999) .

Background Reference 03

The MGC Project Team, Genome Res. 14:2121-2127 (2004) .

Other Product Names

CTBP, C-terminal binding protein 1, EC 1.1.1

Tested Applications

WB, IHC

Protein ID

4557497

Physical Properties

Liquid

Frequently Asked Questions

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