Claudin 5 (phospho Tyr217) Antibody

Product Specifications

Background

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.

NCBI Gene ID

7122

Swiss Prot

O00501

Accession Number

NP_001124333.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Claudin 5 (phospho Tyr217) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 217 (K-K-N-Y (p) -V) derived from Human Claudin 5.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

23 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of Claudin 5 only when phosphorylated at tyrosine 217.

Symbol

CLDN5

NCBI Official Name

Claudin 5

NCBI Organism

Homo sapiens

Background Reference 01

Sirotkin H., Genomics 42:245-251 (1997) .

Background Reference 02

Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11 (2004) .

Background Reference 03

The MGC Project Team; Genome Res. 14:2121-2127 (2004) .

Other Product Names

CLD5, CLDN5, TMDVCF

Tested Applications

IHC

Protein ID

6685271

Physical Properties

Liquid

Curated Selection

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