Claudin 3 (phospho Tyr219) Antibody

Product Specifications

Background

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands.

NCBI Gene ID

1365

Swiss Prot

O15551

Accession Number

NP_001297.1

Host

Rabbit

Reactivity

Human

Immunogen

Claudin 3 (phospho Tyr219) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 219 (R-K-D-Y (p) -V) derived from Human Claudin 3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

28 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of Claudin 3 only when phosphorylated at tyrosine 219.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

CLDN3

NCBI Official Name

Claudin 3

NCBI Organism

Homo sapiens

Background Reference 01

Peacock R.E., Genomics 46:443-449 (1997) .

Background Reference 02

Katahira J., J. Biol. Chem. 272:26652-26658 (1997) .

Background Reference 03

The MGC Project Team; Genome Res. 14:2121-2127 (2004) .

Other Product Names

CLD3, CLDN3, HRVP1, CPE-R 2, CPE-receptor 2

Tested Applications

Protein ID

6685273

Physical Properties

Liquid

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