CDC25C (phospho Ser198) Antibody

Product Specifications

Background

Cdc25C is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.

NCBI Gene ID

995

Swiss Prot

P30307

Accession Number

NP_001274511.1

Host

Rabbit

Reactivity

Human

Immunogen

CDC25C (phospho Ser198) antibody was raised against a peptide sequence around phosphorylation site of Serine 198 (E-F-S (p) -L-K) derived from Human CDC25C.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

53 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of CDC25C only when phosphorylated at serine 198.

Symbol

CDC25C

NCBI Official Name

Cell division cycle 25C

NCBI Organism

Homo sapiens

Background Reference 01

Sadhu K., Proc. Natl. Acad. Sci. U.S.A. 87:5139-5143 (1990) .

Background Reference 02

Bureik M., Int. J. Oncol. 17:1251-1258 (2000) .

Background Reference 03

Wegener S., Eur. J. Cell Biol. 79:810-815 (2000) .

Other Product Names

CDC25M1, MPI1B, MPIP3, EC 3.1.3.48

Tested Applications

IHC

Protein ID

12408658

Physical Properties

Liquid

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