ATF-2 (phospho Ser472) Antibody

Product Specifications

Background

Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.

NCBI Gene ID

1386

Swiss Prot

P15336

Accession Number

NP_001243019.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

ATF-2 (phospho Ser472) antibody was raised against a peptide sequence around phosphorylation site of Serine 472 (E-A-V (p) -A-T) derived from Human ATF-2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

54 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of ATF-2 only when phosphorylated at serine 472.

Symbol

ATF2

NCBI Official Name

Activating transcription factor 2

NCBI Organism

Homo sapiens

Background Reference 01

Maekawa T., EMBO J. 8:2023-2028 (1989) .

Background Reference 02

Yang L., J. Immunol. 158:2522-2525 (1997) .

Background Reference 03

Kara C.J., Mol. Cell. Biol. 10:1347-1357 (1990) .

Other Product Names

Activating 2, ATF2, cAMP response element binding protein CRE- BP1, CREB2, HB16

Tested Applications

IHC

Protein ID

22538422

Physical Properties

Liquid

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