AIRE (phospho Ser156) Antibody

Product Specifications

Background

The function of the protein encoded by this gene is not well defined, however it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described [1]. The longer AIRE-1 mRNA appears to be more abundant and includes exons 1 through 14. Splice variant AIRE-2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 through 14. Variant AIRE-3 includes the same exon 1-8-9 sequences as found in AIRE-2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized.

NCBI Gene ID

326

Swiss Prot

O43918

Accession Number

NP_000374.1

Host

Rabbit

Reactivity

Human

Immunogen

AIRE (phospho Ser156) antibody was raised against a peptide sequence around phosphorylation site of Serine156 P-G-S (p) -Q-L) derived from Human AIRE.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

50 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of AIRE only when phosphorylated at serine 156.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

AIRE

NCBI Official Name

Autoimmune regulator

NCBI Organism

Homo sapiens

Background Reference 01

Nagamine K., Nat. Genet. 17:393-398 (1997) .

Background Reference 02

Aaltonen J., Nat. Genet. 17:399-403 (1997) .

Background Reference 03

Hattori M., Nature 405:311-319 (2000) .

Other Product Names

AIRE1, APECED, APS1, APSI, PGA1

Tested Applications

Protein ID

4557291

Physical Properties

Liquid

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