Caveolin 2 (phospho Tyr27) Antibody

Product Specifications

Background

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.

NCBI Gene ID

858

Swiss Prot

P51636

Accession Number

NP_001224.1

Host

Rabbit

Reactivity

Human

Immunogen

Caveolin 2 (phospho Tyr27) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 27 (L-E-Y (p) -A-D) derived from Human Caveolin 2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

26 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of Caveolin 2 only when phosphorylated at tyrosine 27.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

CAV2

NCBI Official Name

Caveolin 2

NCBI Organism

Homo sapiens

Background Reference 01

Scherer P.E., Proc. Natl. Acad. Sci. U.S.A. 93:131-135 (1996) .

Background Reference 02

Scherer P.E., J. Biol. Chem. 272:29337-29346 (1997) .

Background Reference 03

Engelman J.A., FEBS Lett. 448:221-230 (1999) .

Other Product Names

CAV2, Caveolin-2

Tested Applications

Protein ID

4557413

Physical Properties

Liquid

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