ITCH (phospho Tyr420) Antibody

Product Specifications

Background

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain.

NCBI Gene ID

83737

Swiss Prot

Q96J02

Accession Number

NP_001244066.1

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

ITCH (phospho Tyr420) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 420 (F-I-Y (p) -G-N) derived from Human ITCH .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

102 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of ITCH only when phosphorylated at tyrosine 420.

Symbol

ITCH

NCBI Official Name

Itchy E3 ubiquitin protein ligase

NCBI Organism

Homo sapiens

Background Reference 01

Chen X., Genomics 73:238-241 (2001) .

Background Reference 02

Deloukas P., Nature 414:865-871 (2001) .

Background Reference 03

Wood J.D., Mol. Cell. Neurosci. 11:149-160 (1998) .

Other Product Names

AIF4, AIP4, NAPP1

Tested Applications

IHC

Protein ID

380420335

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MBS126928-01 0.02 mL

NKX2-1 Polyclonal Antibody

Ask

View Details

MBS126928-02 0.1 mL

NKX2-1 Polyclonal Antibody

Ask

View Details

MBS126928-03 5x 0.1 mL

NKX2-1 Polyclonal Antibody

Ask

View Details

214554 100 µL

Calretinin discontinued

Ask

View Details

GT19377 100 µg

Purified anti-STAT1 Phospho (Ser727)

Ask

View Details

MBS2066380-01 0.1 mL

FITC-Linked Polyclonal Antibody to Heart And Neural Crest Derivatives Expressed Protein 1 (HAND1)

Ask

View Details