FGFR1/2 (phospho Tyr463/466) Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.

NCBI Gene ID

2260;2263

Swiss Prot

P11362; P21802

Accession Number

NP_075598.2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

FGFR1/2 (phospho Tyr463/466) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 463/466 (S-E-Y (p) -E-L) derived from Human FGFR1/2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

91 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of FGFR1/2 only when phosphorylated at tyrosine 463/466.

Symbol

FGFR1, FGFR2

NCBI Official Name

Fibroblast growth factor receptor 1, fibroblast growth factor receptor 2

NCBI Organism

Homo sapiens

Background Reference 01

Itoh N., Biochem. Biophys. Res. Commun. 169:680-685 (1990) .

Background Reference 02

Dionne C.A., EMBO J. 9:2685-2692 (1990) .

Background Reference 03

Johnson D.E., Mol. Cell. Biol. 10:4728-4736 (1990) .

Other Product Names

BFGFR, CEK, FLG, CD331, FLT2

Tested Applications

Protein ID

291327489

Physical Properties

Liquid

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