GRB2 (phospho Ser159) Antibody

Product Specifications

Background

This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.

NCBI Gene ID

9846

Swiss Prot

Q9UQC2

Accession Number

NP_536739.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

GRB2 (phospho Ser159) antibody was raised against a peptide sequence around phosphorylation site of Serine 159 (K-S-S (p) -A-P) derived from Human GRB2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

100 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of GRB2 only when phosphorylated at serine 159.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

GAB2

NCBI Official Name

GRB2-associated binding protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Nishida K., Blood 93:1809-1816 (1999) .

Background Reference 02

Nagase T., DNA Res. 5:31-39 (1998) .

Background Reference 03

Taylor T.D., Nature 440:497-500 (2006) .

Other Product Names

GABJ, KIAA0571, pp100

Tested Applications

Protein ID

18105042

Physical Properties

Liquid

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