DDR1 (phospho Tyr513) Antibody

Product Specifications

Background

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI) .

NCBI Gene ID

780

Swiss Prot

Q08345

Accession Number

NP_001189450.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

DDR1 (phospho Tyr513) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 513 (K-K-Y (p) -V-R) derived from Human DDR1 .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

110 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of DDR1 only when phosphorylated at tyrosine 513.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

DDR1

NCBI Official Name

Discoidin domain receptor tyrosine kinase 1

NCBI Organism

Homo sapiens

Background Reference 01

Di Marco E., J. Biol. Chem. 268:24290-24295 (1993) .

Background Reference 02

Johnson J.D., Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681 (1993) .

Background Reference 03

Laval S., Cell Growth Differ. 5:1173-1183 (1994) .

Other Product Names

CAK, RTK6, TRKE, EDDR1

Tested Applications

WB, IHC

Protein ID

729008

Physical Properties

Liquid

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