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FRS2 (phospho Tyr436) Antibody

Product Specifications

Background

FRS2 is an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways.

NCBI Gene ID

10818

Swiss Prot

Q8WU20

Accession Number

NP_001036020.1

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

FRS2 (phospho Tyr436) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 436 (L-N-Y (p) -I-Q) derived from Human FRS2 .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

65 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of FRS2 only when phosphorylated at tyrosine 436.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

FRS2

NCBI Official Name

Fibroblast growth factor receptor substrate 2

NCBI Organism

Homo sapiens

Background Reference 01

Xu H., J. Biol. Chem. 273:17987-17990 (1998) .

Background Reference 02

Meakin S.O., J. Biol. Chem. 274:9861-9870 (1999) .

Background Reference 03

Dhalluin C., Mol. Cell 6:921-929 (2000) .

Other Product Names

SNT-1, SNT2, FGFR signalling adaptor

Tested Applications

WB, IHC

Protein ID

110347408

Physical Properties

Liquid

Curated Selection

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