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HP1γ (phospho Ser93) Antibody

Product Specifications

Background

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.

NCBI Gene ID

11335;653972

Swiss Prot

Q13185

Accession Number

NP_009207.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

HP1γ (phospho Ser93) antibody was raised against a peptide sequence around phosphorylation site of Serine 93 (R-L-S (p) -L-S) derived from Human HP1γ .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=79-879

Calculated Molecular Weight

24 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of HP1γ only when phosphorylated at serine 93.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

CBX3

NCBI Official Name

Chromobox homolog 3

NCBI Organism

Homo sapiens

Background Reference 01

Ye Q., J. Biol. Chem. 271:14653-14656 (1996) .

Background Reference 02

Ye Q., Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.

Background Reference 03

Koike N., FEBS Lett. 467:17-21 (2000)

Other Product Names

HECH, HP1 gamma, HP1Hs-gamma, chromobox 3

Tested Applications

WB

Protein ID

15082258

Physical Properties

Liquid

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