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INOS (phospho Tyr151) Antibody

Product Specifications

Background

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.

NCBI Gene ID

4843

Swiss Prot

P35228

Accession Number

NP_000616.3

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

INOS (phospho Tyr151) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 151 (Q-Y-Y (p) -G-S) derived from Human iNOS .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

131 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of Inos only when phosphorylated at tyrosine 151.

Symbol

NOS2

NCBI Official Name

Nitric oxide synthase 2, inducible

NCBI Organism

Homo sapiens

Background Reference 01

Geller D.A., Proc. Natl. Acad. Sci. U.S.A. 90:3491-3495 (1993) .

Background Reference 02

Sherman P.A., Biochemistry 32:11600-11605 (1993) .

Background Reference 03

Charles I.G., Proc. Natl. Acad. Sci. U.S.A. 90:11419-11423 (1993) .

Other Product Names

HEP-NOS, NOS2, inducible

Tested Applications

IHC

Protein ID

1352513

Physical Properties

Liquid

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