Trk B (phospho Tyr706/Tyr707) Antibody

Product Specifications

Background

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF) . Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

NCBI Gene ID

4915

Swiss Prot

Q16620

Accession Number

NP_001018074.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Trk B (phospho Tyr706/Tyr707) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 706/tyrosine 707 (T-D-Y (p) -Y (p) -R-V) derived from Human Trk B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

91 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of Trk B only when phosphorylated at tyrosine 706 and tyrosine 707.

Symbol

NTRK2

NCBI Official Name

Neurotrophic tyrosine kinase, receptor, type 2

NCBI Organism

Homo sapiens

Background Reference 01

Nakagawara A., Genomics 25:538-546 (1995) .

Background Reference 02

Shelton D.L., J. Neurosci. 15:477-491 (1995) .

Background Reference 03

Stoilov P., Biochem. Biophys. Res. Commun. 290:1054-1065 (2002) .

Other Product Names

Trk-B, NTRK2, GP145-TrkB

Tested Applications

IHC

Protein ID

2497560

Physical Properties

Liquid

Curated Selection

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