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Trk A (phospho Tyr757) Antibody

Product Specifications

Background

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF) . Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

NCBI Gene ID

4914

Swiss Prot

P04629

Accession Number

NP_002520.2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Trk A (phospho Tyr757) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 757 (E-V-Y (p) -A-I) derived from Human Trk A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

87 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of Trk A only when phosphorylated at tyrosine 757.

Symbol

NTRK1

NCBI Official Name

Neurotrophic tyrosine kinase, receptor, type 1

NCBI Organism

Homo sapiens

Background Reference 01

Martin-Zanca D., Mol. Cell. Biol. 9:24-33 (1989) .

Background Reference 02

Shelton D.L., J. Neurosci. 15:477-491 (1995) .

Background Reference 03

The MGC Project Team, Genome Res. 14:2121-2127 (2004) .

Other Product Names

TRKA, TRK, NTRK1, p140-TrkA

Tested Applications

IHC

Protein ID

94730402

Physical Properties

Liquid

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