RSK1/2/3/4 (phospho Ser221/227/S218/232) Antibody

Product Specifications

Background

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway.

NCBI Gene ID

6195;6197;6196;27330

Swiss Prot

Q15418; P51812; Q15349; Q9UK32

Accession Number

NP_002944.2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

RSK1/2/3/4 (phospho Ser221/227/S218/232) antibody was raised against a peptide sequence around phosphorylation site of Serine 221/227/218/232 (A-Y-S (p) -F-C) derived from Human RSK1/2/3/4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20&#730, C for up to one year.

Calculated Molecular Weight

85 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of RSK1/2/3/4 only when phosphorylated at serine 221/227/218/232.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6

NCBI Official Name

Ribosomal protein S6 kinase, 90kDa, polypeptide 1, ribosomal protein S6 kinase, 90kDa, polypeptide 2, ribosomal protein S6 kinase, 90kDa, polypeptide 3, ribosomal protein S6 kinase, 90kDa, polypeptide 6