PEK/PERK (phospho Thr982) Antibody

Product Specifications

Background

Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR) -induced G1 growth arrest due to the loss of cyclin-D1 (CCND1)

NCBI Gene ID

9451

Swiss Prot

Q9NZJ5

Accession Number

NP_004827.4

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

PEK/PERK (phospho Thr982) antibody was raised against a peptide sequence around phosphorylation site of threonine 981 (A-R-H (p) -T-G) derived from Human PEK/PERK.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

125 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of PEK/PERK only when phosphorylated at threonine 981.

Symbol

EIF2AK3

NCBI Official Name

Eukaryotic translation initiation factor 2-alpha kinase 3

NCBI Organism

Homo sapiens

Background Reference 01

Shi Y., An J., J. Biol. Chem. 274:5723-5730 (1999) .

Background Reference 02

Sood R., Biochem. J. 346:281-293 (2000) .

Background Reference 03

The MGC Project Team; Genome Res. 14:2121-2127 (2004) .

Other Product Names

E2AK3, PERK, PEK, EIF2AK3

Tested Applications

IHC

Protein ID

296439367

Physical Properties

Liquid

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