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MYT1 (phospho Ser83) Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

NCBI Gene ID

9088

Swiss Prot

Q99640

Accession Number

XP_006721039.1

Host

Rabbit

Reactivity

Human

Immunogen

MYT1 (phospho Ser83) antibody was raised against a peptide sequence around phosphorylation site of Serine 83 (R-V-S (p) -F-R) derived from Human MYT1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

54 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of MYT1 only when phosphorylated at serine 83.

Symbol

PKMYT1

NCBI Official Name

Protein kinase, membrane associated tyrosine/threonine 1

NCBI Organism

Homo sapiens

Background Reference 01

Booher R.N., J. Biol. Chem. 272:22300-22306 (1997) .

Background Reference 02

Liu F., Mol. Cell. Biol. 17:571-583 (1997) .

Background Reference 03

Nousiainen M., Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396 (2006) .

Other Product Names

PMYT1, PKMYT1, MYT1 kinase

Tested Applications

IHC

Protein ID

33383241

Physical Properties

Liquid

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