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MLK1/2 (phospho Thr312/266) Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.

NCBI Gene ID

4293;4294

Swiss Prot

P80192; Q02779

Accession Number

NP_001271159.1

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

MLK1/2 (phospho Thr312/266) antibody was raised against a peptide sequence around phosphorylation site of threonine 312/266 (A-G-T (p) -Y-A) derived from Human MLK1/2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20&#730, C for up to one year.

Calculated Molecular Weight

121 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of MLK1/2 only when phosphorylated at threonine 312/266.

Symbol

MAP3K9, MAP3K10

NCBI Official Name

Mitogen-activated protein kinase kinase kinase 9, mitogen-activated protein kinase kinase kinase 10

NCBI Organism

Homo sapiens

Background Reference 01

Durkin J.T., Biochemistry 43:16348-16355 (2004) .

Background Reference 02

The MGC Project Team, Genome Res. 14:2121-2127 (2004) .

Background Reference 03

Dorow D.S., Nature 446:153-158 (2007) .

Other Product Names

M3K9, PRKE1, mixed-lineage protein kinase 1

Tested Applications

IHC

Protein ID

52421790

Physical Properties

Liquid

Frequently Asked Questions

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